having gone 12.5:1 on a street motor, I can say my new max comp ratio for 93 octane is 11.8:1 - at least at this elevation and with our summer weather. You just don't have the wiggle room you need for tuning.

Also, as I believe that there is only one reason raising compression to any significant degree should be done, and that is to support more aggressive cams.

My point is, come at it from the other direction. Big cams make power but bleed off compression, so what do you need to maximize power? Answer is more compression. Just raising compression for the sake of compression never made much sense to me. It's part of a strategy to support other elements of the build, imo.

I would decide on cams and then match compression to fit them.