the answer is yes, but the car becomes so nose heavy it's no longer a 240sx. it's no longer an s chassis that is amazingly nimble.
its now a supra.
so yes, if you want a supra, go buy a supra! you can make a 500hp 240sx, but it will be with an rb and heavier than a 500hp sr powered 240sx. what happens then? you get beaten, of course.
if money isnt an issue, whatever engine has the most money into it will go the fastest. there are 1000+hp SR cars in japan.
rbs are not as un breakable as you may think.