Not trying to be rude or anything, but If you want MPG , don't get an underpowered, 220hp V8, 5,000lb truck?
You can dial the truck in for the type of driving you do (i.e. city, highway, mixed) with a tune and gears, but I bet you only get 1 or 2 mpg improvement.
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"Genuine" ASE certified Mazda, Hyundai, Isuzu Technician
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Automotive Electrical Specialist, Tuning Specialist