My parents have owned two and I have owned one. None of those 3 have ever let us down. My dad had a 94 V6 that went 140k miles before he sold it. It looked like crap but still ran fine, and he doesn't really do preventative maintenance either. He sold it because my mom got a Charger and turned over her 98 V6 to him. He now has 140k miles on it and it still drives fine and pulls small/medium trailers regularly.

We have a 2000 quad cab with the 4.7. It has over 70k miles and has had no issues.

The only thing we've replaced on any of these trucks is the fuel pump (one each). They made noise, but never left us stranded.

They are easy to work on, parts are fairly priced, and they are nice and roomy inside. They are a great alternative to a true full size truck but still get decent gas mileage and can tow decent loads.