This should help you understand.
Most rear drive cars have a 1 to 1, 4th gear which means that the power path goes directly through the mainshaft of the transmission. The only losses here are bearing drag which is less than 0.5% and the viscous drag of the gears running through the oil which is about 1% with hot oil. Indeed, published data indicates a transmission efficiency of 98 to 98.5% for conventional transmissions in 4th gear.