ok....im assuming youre camparing to a GSR motor. let say with all the same mods in each motor.

LS/VTEC

good- price/availability of block, and extra displacement

bad- rod/stroke ratio, not as safe for high revs, no oil squirters

GSR

good- made for vtec, no modifications are necessary for head, better rod/stroke ratio for high revving, stronger rods, better oil lubrication

bad- availability/price, 37cc less than LS block(not quite a negative tho)