Stay on 275 until you get to the Gandy Blvd exit (I believe its the exit after 54th Ave NORTH). When you get to the bottom of the off ramp go left. You'll go under 275 thru a stop light and then over a bridge. After you go over the bridge you'll come to another stop light, go left at that light into the shopping plaza. Target is in there. Its only about 2 miles from the time you turn left off the off ramp of 275 to the plaza.

Just FYI, The Gandy exit is a little bit of a hike after you get off the skyway. Its past Tropicana Field, but If you get to the Howard Franklin bridge you've gone too far.

Hope that helps.