If you are going to run nitrous and have a chip, make sure it is specifically programmed for nitrous. Any chip for an all motor VR will advance timing and running nitrous with too much advanced timing can cause detonation. Also, there have been issues with a wet set-up on the VR6 in the past. Due to intake manifold design, fuel can puddle in the manifold, then when you turn the car on, boom, your mani will explode.

I haven't read much recently on nitrous use on VR6's, but I do know some people that ran it for a while and didn't have any problems.

And for the record, you won't get 300 hp with a nitrous set-up on a VR6 unless it is a well built set-up. Then for the money, you could have gone turbo and have a more reliable set-up that you could use everyday.