You are confusing me, now. In your original post you said you had 525cc injectors. 440cc also are too big for your application in my opinion, though it is more reasonable to dial that size down with a new fuel map than it would 525cc.
Still, keep in mind proper injectors for a 200 hp street engine are 310cc or 320cc. Note that the integra type Rs at 200 hp came with 240cc injectors and an H22 engine rated at 195 hp came with 270cc or 280cc (as I recall). My calculation shows 440cc support about 300 hp at 100 percent of duty cycle, making them ideal for something putting out perhaps 250+hp. Speaking of H22 injectors, using them on a b18 vetc buildup is a pretty common upgrade.
Regarding 440cc, if that is what you are running, never tried to detune them but if you have your a/f good across the rpm range, I would say your tuner worked it out. Just saying, when you are selecting injectors for the type of build you have, 440 and most certainly 525s would be over the top.
Remember, you increase fuel so you can keep up with increased air flow. Nothing short of some very radical intake porting and manifold work (ITBs maybe or some boost, of course) would ever get you so much air that you needed injectors that big.
I would worry that the fuel map would be all over the place from idle to rev limit.
I saw a case of 440cc injectors left in a GSR motor after a turbo with small boost setup was converted back to a stock setup. It would start and choke on fuel. Even keeping the revs up it was drowning in gas and dying out.
The map might have been adjusted to deal with 440s, but why fight it? The 240cc stock injectors went back in and solved the problem.
It's all about proportions and balance and while you can always try to shift things around to try and make it work, a canoe with a 550 lb passenger capacity will be happier with a couple 225 pound people than one 440 pound dude and his 110 lb girlfriend.