I used it, but I sold it after I sold my z06.
It seemed very intuitive to use to me..And there was plenty of help availible via their forums. I never had a problem with it on the 3 different computers I used it on. I managed to use it to get about 368/373 rwhp/rwtq on my z06 with just headers at coastal dyno in 93 degree heat.
If you've got an ls1/ls6 you definitely need something to tune it, and HPtuners is the best thing out there right now IMO.