yes, if you use one channel per sub. you can bridge the channels to get a lil more power, ill try and make a diagram as simply as i can... O= a sub, and ----- or / or \ = speaker wire

Bridged:
Amp + ---O
Amp - &nbsp&nbsp \/
Amp + &nbsp /\
Amp -_/__\
&nbsp&nbsp&nbsp&nbsp&nbsp&nbsp&nbsp&nbsp&nbsp&nbsp &nbsp&nbsp&nbsp&nbsp&nbsp&nbspO

Not bridged:
Amp + __O
Amp - __/
Amp +__
Amp - __\
&nbsp&nbsp&nbsp&nbsp&nbsp&nbsp&nbsp&nbsp&nbsp&nbsp &nbsp&nbsp&nbsp&nbspO

A 4 channel amp will have 4+ and 4- speaker outputs on the amp. A 2 channel amp will have 2+ and 2- outputs. If you get the 4 channel, you can bridge it to get more power, aka use the positive from one channel and the negative from a 2nd channel. Id recommend bridging it, so you wont have to turn the Gain/Level on the amp as high, because the higher you turn the gain up, not only will you get a lil more distortion (prolly not noticeable) but also the amp might overheat and cut out.